Kevinmcgee Week 5

Uniprot Exercise

1. • EMBL stands for European Molecular Biology Lab. It is a database that holds a large amount of protein/gene databases. Similar to Genbank and DDBJ
   • InterPro is a database for protein sequence, analysis, and classification. Owned by the European Bioinformatics Institute (EBI).
   • On Uniprot, there are three different PDB databases. PDB stands for Protein Data Bank, and they contain 3D structures of proteins.
   • Pfam is a collection of protein domains to easily look at the domains of a protein and what that tells us about that protein.
   • RefSeq stands for Reference Sequence collection, which is a US owned database of protein, DNA, and gene sequences. It provides summaries and documents on the sequences it contains.
   • Geneid is a database that further identifies and describes the EFGR and how it relates to genes. For instance, it gives the location of EFGR on a chromosome, and how EFGR relates to patients with ling cancer.
2. EFGR is a protein that is a receptor for the epidermal growth factor and is also a member of the kinase family. If bonded to a ligand, it leads to cell proliferation. Found on the surface of a cell. EFGR mutations have also been known to be associated with lung cancer.
3. • The purpose of this assignment was to understand all the different datatbases used in biology and how they interrelate to one another.
   • I learned about the different types of databases and about the properties of EFGR.
   • I am still confused as to why there are so many different databases, and why they cannot keep all the information on a single database. It seems easier to me to have all the information in one place.