Kevinmcgee Week 10

1. • I used the PubMed database to find the reference geneome of Leishmania Major.
   • I searched with the terms "Leishmania Major [MeSH Terms] AND Genome [Title]"
   • The search terms came back with 30 articles
   • The 9th article was titled: The Genome of the kinetoplastid parasite, Leishmania Major (Ivens et al., 2005) This is the reference genome.
   • Link to Article Online
2. • On Web of Science, I searched using the search terms "Leishmania Major" for the Title and "Ivens AC" for the author.
   • I got 7 article results back from my search terms. The 1st article was the reference genome that I found on PubMed.
   • The last thing that Ivens published was the genome sequence and has not had published work on Leishmania Major since then. However, looking at the people who have referenced his reference genome, you can see many of the directions people have taken his research. Many articles have been posted in the last year on determining Leishmania resistance to drugs and many properties of different proteins within the gene.
3. • Didn't find any good sources on Leishmania microarray data. Went to ArrayExpress, to look for arrays on Leishmania major to backtrack to articles.
   • I typed in "Leishmania Major" in the organism field and "Array assay" in the technology field and filtered down my results.
   • Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy. Found on ArrayExpress
   • Genome-wide gene expression profiling analysis of Leishmania major and Leishmania infantum developmental stages reveals substantial differences between the two species. Found on ArrayExpress