ADH1 | YOL086C | Alcohol DeHydrogenase

Database	Gene ID
SGD	S000005446
Gene Database	854068
Ensembl	YOL086C
UniProt	P00330

ATGTCTATCC CAGAAACTCA AAAAGGTGTT ATCTTCTACG AATCCCACGG TAAGTTGGA

TACAAAGATA TTCCAGTTCC AAAGCCAAAG GCCAACGAAT TGTTGATCAA CGTTAAATAC

TCTGGTGTCT GTCACACTGA CTTGCACGCT TGGCACGGTG ACTGGCCATT GCCAGTTAAG

CTACCATTAG TCGGTGGTCA CGAAGGTGCC GGTGTCGTTG TCGGCATGGG TGAAAACGTT

AAGGGCTGGA AGATCGGTGA CTACGCCGGT ATCAAATGGT TGAACGGTTC TTGTATGGCC

TGTGAATACT GTGAATTGGG TAACGAATCC AACTGTCCTC ACGCTGACTT GTCTGGTTAC

ACCCACGACG GTTCTTTCCA ACAATACGCT ACCGCTGACG CTGTTCAAGC CGCTCACATT

CCTCAAGGTA CCGACTTGGC CCAAGTCGCC CCCATCTTGT GTGCTGGTAT CACCGTCTAC

AAGGCTTTGA AGTCTGCTAA CTTGATGGCC GGTCACTGGG TTGCTATCTC CGGTGCTGCT

GGTGGTCTAG GTTCTTTGGC TGTTCAATAC GCCAAGGCTA TGGGTTACAG AGTCTTGGGT

ATTGACGGTG GTGAAGGTAA GGAAGAATTA TTCAGATCCA TCGGTGGTGA AGTCTTCATT

GACTTCACTA AGGAAAAGGA CATTGTCGGT GCTGTTCTAA AGGCCACTGA CGGTGGTGCT

CACGGTGTCA TCAACGTTTC CGTTTCCGAA GCCGCTATTG AAGCTTCTAC CAGATACGTT

AGAGCTAACG GTACCACCGT TTTGGTCGGT ATGCCAGCTG GTGCCAAGTG TTGTTCTGAT

GTCTTCAACC AAGTCGTCAA GTCCATCTCT ATTGTTGGTT CTTACGTCGG TAACAGAGCT

GACACCAGAG AAGCTTTGGA CTTCTTCGCC AGAGGTTTGG TCAAGTCTCC AATCAAGGTT

GTCGGCTTGT CTACCTTGCC AGAAATTTAC GAAAAGATGG AAAAGGGTCA AATCGTTGGT

AGATACGTTG TTGACACTTC TAAATAA

MSIPETQKGVIFYESHGKLEYKDIPVPKPKANELLINVKYSGVCHTDLHAWHGDWPLPVK

LPLVGGHEGAGVVVGMGENVKGWKIGDYAGIKWLNGSCMACEYCELGNESNCPHADLSGY

THDGSFQQYATADAVQAAHIPQGTDLAQVAPILCAGITVYKALKSANLMAGHWVAISGAA

GGLGSLAVQYAKAMGYRVLGIDGGEGKEELFRSIGGEVFIDFTKEKDIVGAVLKATDGGA

HGVINVSVSEAAIEASTRYVRANGTTVLVGMPAGAKCCSDVFNQVVKSISIVGSYVGNRA

DTREALDFFARGLVKSPIKVVGLSTLPEIYEKMEKGQIVGRYVVDTSK

ADH is of the 5 genes in S. cerevisiae (baker's yeast) that encode alcohol dehydrogenase involved in ethanol metabolism. The ADH 1 gene codes for an enzyme that reduces acetaldehyde to ethanol during glucose fermentation. This enzyme is also involved in the production of fusel alcohols, or end products of amino acid catabolism via the Ehrlich pathway, during fermentation. These fusel alcohols contribute to the flavor and aroma of yeast-fermented foods and beverages as well as holding physiological roles like stimulating filamentous growth.

The content on each site was in harmony with each other, in fact, some of the sites even referenced the others. All four websites (SGD, NCBI, UniProt, and Ensembl) provide information such as the gene name, a short summary of the gene, and the genetic sequence. NCBI listed articles related to my search topic (ADH1) in PubMed, articles that referenced its function, and a list of pathways from BioSystems. The UniProt website focused on the specifics of the gene for example the nucleotide bindings and binding sites and a description of what they are. Ensembl and SGD provided the most information, including information on the sequence, the protein, the gene ontology, a short summary and more. The presentation of this information differed slightly in that SGD expressed the DNA and Protein sequences separately while Ensembl provided the DNA sequence and underneath it the protein sequence that corresponded to its specific sequence of DNA. Some websites showed the location of the gene on the chromosome by just giving the number location while other websites showed a diagram of the chromosome and ADHI on the chromosome with its neighboring genes. The differences in the websites allowed for a useful combination of them all in order to acquire the most information about the gene.

John Lopez

I worked with my partner Dina Bashoura in class. We decided on our gene and decided how we wanted this organized. On Sunday we FaceTimed to construct the website, where we finished most of it. On Monday we met to finalize everything and submitted. For the project, I worked on constructing the site, while Dina did the research. While I worked with the people noted above, this individual journal entry was completed by me and not copied from another source.

Dina Bashoura

I worked with my partner John Lopez in class. We decided on our gene and decided how we wanted this organized. On Sunday we FaceTimed to construct the website, where we finished most of it. On Monday we met to finalize everything and submitted. For the project, I did all the research needed and wrote the text, while John worked on the HTML. While I worked with the people noted above, this individual journal entry was completed by me and not copied from another source.