ADA2 is a gene that is not required for cell survival. However, cells that lack the gene have been identified to carry out altered transcription of other genes, have weaker cell walls, decreased growth rates, and demonstrate increased sensitivity to environmental conditions (i.e. pH, heat, chemicals, etc.) Expression of ADA2 contributes directly to the production of chromatin modifying histone acetyltransferase complexes. These complexes are responsible for altering the structure of DNA to both allow for or deny transcription of various genes. (Emsembl. 2017) (NCBI. 2017) (SDG. 2017) (UniProt. 2017)
0001 ATGTCAAACA AGTTTCACTG TGACGTTTGT TCAGCTGATT GCACGAACAG AGTGAGGGTT
0061 TCATGTGCTA TTTGTCCCGA ATACGACTTA TGCGTGCCCT GCTTTTCACA AGGCTCGTAT
0121 ACAGGAAAGC ATCGCCCTTA CCATGATTAT AGGATAATAG AGACCAATTC ATACCCCATT
0181 CTCTGTCCTG ATTGGGGTGC CGATGAAGAA TTGCAGTTGA TTAAAGGCGC ACAGACTTTA
0241 GGGCTCGGTA ATTGGCAGGA TATTGCTGAC CATATAGGCA GCAGAGGCAA AGAAGAAGTT
0301 AAGGAACATT ACCTAAAATA TTATCTGGAA AGCAAATACT ATCCAATACC TGATATTACC
0361 CAAAATATAC ATGTCCCACA AGATGAATTT TTGGAACAGC GAAGGCATAG AATCGAGTCC
0421 TTCCGGGAGA GGCCGCTAGA GCCTCCAAGA AAGCCCATGG CATCGGTTCC TAGCTGCCAT
0481 GAAGTACAGG GGTTTATGCC GGGCAGATTA GAATTTGAAA CAGAATTCGA AAATGAAGCT
0541 GAAGGTCCCG TAAAGGATAT GGTTTTTGAA CCTGATGACC AGCCCTTAGA CATTGAATTG
0601 AAGTTTGCCA TCTTGGACAT TTACAATTCT AGATTGACAA CCAGAGCAGA AAAGAAAAGG
0661 CTATTATTTG AAAACCATTT AATGGATTAC AGAAAGTTGC AAGCTATTGA CAAAAAGAGG
0721 AGCAAAGAAG CCAAAGAATT GTATAACCGC ATAAAACCTT TTGCTCGTGT TATGACTGCA
0781 CAGGATTTTG AGGAATTTAG CAAGGATATA TTAGAAGAAT TGCATTGCAG GGCAAGAATA
0841 CAGCAATTAC AAGAATGGAG AAGCAATGGG TTAACCACGT TAGAAGCAGG TCTTAAGTAT
0901 GAACGAGATA AGCAAGCTAG AATTAGCAGT TTCGAGAAAT TTGGCGCTTC TACGGCGGCG
0961 TCACTCAGTG AGGGCAATAG CCGTTATAGG TCGAATTCTG CACATAGGTC GAACGCAGAA
1021 TACAGCCAAA ACTACAGCGA AAATGGCGGT AGAAAGAAAA ATATGACCAT TAGCGATATA
1081 CAGCATGCAC CTGACTATGC ACTGTTGTCC AACGACGAGC AGCAACTTTG TATTCAACTG
1141 AAAATTTTAC CTAAACCGTA TCTCGTTCTA AAAGAGGTAA TGTTCAGAGA ACTGTTGAAG
1201 ACTGGGGGTA ATCTAAGCAA AAGCGCATGT AGGGAACTAC TTAATATAGA CCCCATAAAA
1261 GCGAATAGAA TATACGATTT TTTCCAGAGC CAGAATTGGA TGTAA
001 MSNKFHCDVC SADCTNRVRV SCAICPEYDL CVPCFSQGSY TGKHRPYHDY RIIETNSYPI
061 LCPDWGADEE LQLIKGAQTL GLGNWQDIAD HIGSRGKEEV KEHYLKYYLE SKYYPIPDIT
121 QNIHVPQDEF LEQRRHRIES FRERPLEPPR KPMASVPSCH EVQGFMPGRL EFETEFENEA
181 EGPVKDMVFE PDDQPLDIEL KFAILDIYNS RLTTRAEKKR LLFENHLMDY RKLQAIDKKR
241 SKEAKELYNR IKPFARVMTA QDFEEFSKDI LEELHCRARI QQLQEWRSNG LTTLEAGLKY
301 ERDKQARISS FEKFGASTAA SLSEGNSRYR SNSAHRSNAE YSQNYSENGG RKKNMTISDI
361 QHAPDYALLS NDEQQLCIQL KILPKPYLVL KEVMFRELLK TGGNLSKSAC RELLNIDPIK
421 ANRIYDFFQS QNWM*
Having learned about transciption earlier in this class, this gene was appealing to us due to its function as a transcription co-activator. And while it's not an essential gene for survival it does improve overall fitness by aiding in the creation of a stronger cell wall (reducing the impact of dangerous external features) and allowing for stronger growth rate. We thought this was pretty cool and since we like to think of ourselves as fit and healthy people we appreciate a gene that aids in improving fitness.