Our favorite gene: ADA2

By Emma Tyrnauer and Quinn Lanners
September 25, 2017


Standard name: ADA2
Systematic Name: YDR448W
Name Description: Transcriptional ADAptor

ADA2 on various databases

SGD

ADA2 ID# = S000002856

Go to SDG page
Go to ADA2 page

NCBI Gene Database

ADA2 ID# = 852059

Go to NCBI Gene Database page
Go to ADA2 page

Ensembl

ADA2 ID# = YDR448W

Go to Ensembl page
Go to ADA2 page

UniProt

ADA2 ID# = YDR448W

Go to UniProt page
Go to ADA2 page

Summary of ADA2 Gene

ADA2 is a gene that is not required for cell survival. However, cells that lack the gene have been identified to carry out altered transcription of other genes, have weaker cell walls, decreased growth rates, and demonstrate increased sensitivity to environmental conditions (i.e. pH, heat, chemicals, etc.) Expression of ADA2 contributes directly to the production of chromatin modifying histone acetyltransferase complexes. These complexes are responsible for altering the structure of DNA to both allow for or deny transcription of various genes. (Emsembl. 2017) (NCBI. 2017) (SDG. 2017) (UniProt. 2017)


Gene Sequence


0001 ATGTCAAACA AGTTTCACTG TGACGTTTGT TCAGCTGATT GCACGAACAG AGTGAGGGTT
0061 TCATGTGCTA TTTGTCCCGA ATACGACTTA TGCGTGCCCT GCTTTTCACA AGGCTCGTAT
0121 ACAGGAAAGC ATCGCCCTTA CCATGATTAT AGGATAATAG AGACCAATTC ATACCCCATT
0181 CTCTGTCCTG ATTGGGGTGC CGATGAAGAA TTGCAGTTGA TTAAAGGCGC ACAGACTTTA
0241 GGGCTCGGTA ATTGGCAGGA TATTGCTGAC CATATAGGCA GCAGAGGCAA AGAAGAAGTT
0301 AAGGAACATT ACCTAAAATA TTATCTGGAA AGCAAATACT ATCCAATACC TGATATTACC
0361 CAAAATATAC ATGTCCCACA AGATGAATTT TTGGAACAGC GAAGGCATAG AATCGAGTCC
0421 TTCCGGGAGA GGCCGCTAGA GCCTCCAAGA AAGCCCATGG CATCGGTTCC TAGCTGCCAT
0481 GAAGTACAGG GGTTTATGCC GGGCAGATTA GAATTTGAAA CAGAATTCGA AAATGAAGCT
0541 GAAGGTCCCG TAAAGGATAT GGTTTTTGAA CCTGATGACC AGCCCTTAGA CATTGAATTG
0601 AAGTTTGCCA TCTTGGACAT TTACAATTCT AGATTGACAA CCAGAGCAGA AAAGAAAAGG
0661 CTATTATTTG AAAACCATTT AATGGATTAC AGAAAGTTGC AAGCTATTGA CAAAAAGAGG
0721 AGCAAAGAAG CCAAAGAATT GTATAACCGC ATAAAACCTT TTGCTCGTGT TATGACTGCA
0781 CAGGATTTTG AGGAATTTAG CAAGGATATA TTAGAAGAAT TGCATTGCAG GGCAAGAATA
0841 CAGCAATTAC AAGAATGGAG AAGCAATGGG TTAACCACGT TAGAAGCAGG TCTTAAGTAT
0901 GAACGAGATA AGCAAGCTAG AATTAGCAGT TTCGAGAAAT TTGGCGCTTC TACGGCGGCG
0961 TCACTCAGTG AGGGCAATAG CCGTTATAGG TCGAATTCTG CACATAGGTC GAACGCAGAA
1021 TACAGCCAAA ACTACAGCGA AAATGGCGGT AGAAAGAAAA ATATGACCAT TAGCGATATA
1081 CAGCATGCAC CTGACTATGC ACTGTTGTCC AACGACGAGC AGCAACTTTG TATTCAACTG
1141 AAAATTTTAC CTAAACCGTA TCTCGTTCTA AAAGAGGTAA TGTTCAGAGA ACTGTTGAAG
1201 ACTGGGGGTA ATCTAAGCAA AAGCGCATGT AGGGAACTAC TTAATATAGA CCCCATAAAA
1261 GCGAATAGAA TATACGATTT TTTCCAGAGC CAGAATTGGA TGTAA

Retrieved from SGD Website

Protein Sequence


001 MSNKFHCDVC SADCTNRVRV SCAICPEYDL CVPCFSQGSY TGKHRPYHDY RIIETNSYPI
061 LCPDWGADEE LQLIKGAQTL GLGNWQDIAD HIGSRGKEEV KEHYLKYYLE SKYYPIPDIT
121 QNIHVPQDEF LEQRRHRIES FRERPLEPPR KPMASVPSCH EVQGFMPGRL EFETEFENEA
181 EGPVKDMVFE PDDQPLDIEL KFAILDIYNS RLTTRAEKKR LLFENHLMDY RKLQAIDKKR
241 SKEAKELYNR IKPFARVMTA QDFEEFSKDI LEELHCRARI QQLQEWRSNG LTTLEAGLKY
301 ERDKQARISS FEKFGASTAA SLSEGNSRYR SNSAHRSNAE YSQNYSENGG RKKNMTISDI
361 QHAPDYALLS NDEQQLCIQL KILPKPYLVL KEVMFRELLK TGGNLSKSAC RELLNIDPIK
421 ANRIYDFFQS QNWM*

Retrieved from SGD Website

Gene Function

Database Breakdown

Pros
Tabs at top of page and side menu allow for easy navigation

Lots of summarizing figures that make data easier to interpret
Cons
Difficult to find when it was last updated
Unique Features
Make a distinction between physical vs. genetic interactions of the gene
Pros
Updated frequently (and date of update noted on top of page)

Table of contents on right hand side make it easy to navigate site

Number of figures to summarize the genetic information
Cons
Very bland and boring format to page (not as appealing to look at)
Unique Features
Had interactive map that allowed for a custom "Find:"" field to quickly find a certain area of the DNA sequence
Pros
Has tabs to view information about the gene as well as its transcript

Also has a left hand navigation bar to easily

Recently updated (as of August this year) and there is a note of the last time the page was updated
Cons
Difficult to find the ID of the gene. There was no explicit title for it anywhere on the page
Unique Features
Had interactive and appealing map of gene location
Pros
Most aesthetically pleasing to look at. Lots of agreeable colors.

Well reviewed (has a 5/5 annotation score - meaning they do an excellent job tracking where their information comes from)

Goes more in depth on the structure of the protein than any of the other databases
Cons
Honestly, this was the best site and you'd have to be quite picky to find any legitimate cons
Unique Features
Toolbar on left of page that allows you to selectively show and/or hide different types of information about the gene

Links to Youtube videos on how to effectively navigate the site



Why we chose ADA2 as our favorite gene

Having learned about transciption earlier in this class, this gene was appealing to us due to its function as a transcription co-activator. And while it's not an essential gene for survival it does improve overall fitness by aiding in the creation of a stronger cell wall (reducing the impact of dangerous external features) and allowing for stronger growth rate. We thought this was pretty cool and since we like to think of ourselves as fit and healthy people we appreciate a gene that aids in improving fitness.


Retrieve raw XML or JSON data from UniProt and SGD


UniProt

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YeastMine (SGD)

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Acknowledgements

References